<-- DOC ID 000318v1 -->


Sirius Medical Magnetic Localization

Initiated by the Netherlands Cancer Institute and University of Twente, an innovative and affordable solution called MaMaLoc (Magnetic Marker Localization) was developed. The patent-pending MaMaLoc technology uses a tiny implanted magnetic seed to precisely mark the tumor and a detection probe to accurately locate the seed during surgery. MaMaLoc is expected to reduce costs by increasing the utilization rate of radiology and surgery departments. At the same time, waiting times can be reduced and patient comfort improved. Experts claim [1] magnetic technologies have the potential to become the standard of care for surgery on breast tumors. With the goal to make the innovation broadly available, the Netherlands Cancer Institute has spun-out the technology into Sirius Medical.

[1] Ahmed, M., Rubio, I. T., Klaase, J. M., & Douek, M. (2015). Surgical treatment of nonpalpable primary invasive and in situ breast cancer. Nature Reviews Clinical Oncology, 12(11), 1–19.

Conventional Systems

The Sirius Medical technology ensures a true single spot localization signal. Designed for precision, we have uniquely solved the challenge of magnetic anisotropy present in conventional magnetic localization systems [2]. We enable accurate detection from every direction and precisely coinciding with the seed location.

[2] Schermers, B., Bennie, ten H., Muller, S., van der Hage, J. A., & Ruers, T. J. M. (2018). Optimization of an implantable magnetic marker for surgical localization of breast cancer. Biomedical Physics & Engineering Express. Retrieved from

Simple and Robust

The Sirius Medical localization system combines the benefits of radioactive seeds such as scheduling flexibility with the additional benefit of intrinsically safe magnetism, obviating the need for burdensome safety protocols. A clinical study has already demonstrated that the system compares favorably to the currently used hook wires and radioactive seeds [3].

Sirius’ rice-grain sized seed is able to mark small lesions of interest in a robust and simple way. Passive magnetic seeds have benefits: Sirius’ magnetic seed will not fail, as the technology relies on intrinsic material properties of the seed that remain unaffected even when hypothetically damaged during use.

[3] Schermers, B., van der Hage, J. A., Loo, C. E., Vrancken Peeters, M. T. F. D., Winter-Warnars, H. A. O., van Duijnhoven, F., Ruers, T. J. M. (2017). Feasibility of magnetic marker localisation for non-palpable breast cancer. The Breast, 33, 50–56.